In this study, we discovered that PC4 was overexpressed in cisplatin-resistant lung adenocarcinoma cells. However, it is still unknown whether PC4 participates in altering the lung adenocarcinoma cell sensitivity to chemotherapy, and the relevant mechanisms remain to be explained. Previous research has shown that PC4 participates in various cellular processes in normal and malignant cells. Positive cofactor 4 (PC4) was at first revealed to be a coactivator of basal transcription. Thus, understanding the relevant mechanisms is urgent. Reduced sensitivity to chemotherapeutic drugs is almost inevitable in lung adenocarcinoma patients.
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